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Both itraconazole and simvastatin can increase the risk of hepatotoxicity. Itraconazole is predicted to increase the exposure to simvastatin. Itraconazole is predicted to increase the exposure to siponimod.

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Therefore, physicians should inform patients that substantial consumption of alcohol e. Tadalafil is metabolized predominantly by CYP3A4 in the liver. The dose erection tadalafil for use as needed should be limited to 10 mg no erectile dysfunction than once every 72 hours in patients taking potent inhibitors of CYP3A4 such as ritonavir, ketoconazole, and itraconazole [see Drug Interactions 7.

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Please refer to the FDA product label for information regarding drug interactions between DLV and other concomitant drugs. The information in the brief version is excerpted directly from the full-text guidelines.

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