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Taking certain anti-seizure drugs with tadalafil may lower the level of tadalafil in your blood. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.

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Systemic drug exposures, as measured by AUC of unbound Tadalafil, were approximately 5-fold for mice, and 7- and 14-fold for male and female rats, respectively, the exposures at the maximum recommended human dose MRHD of 40 mg. Mutagenesis problems with erection Tadalafil was not mutagenic in the in vitro bacterial Ames assays or forward mutation test in mouse lymphoma cells. Tadalafil was not clastogenic in the in vitro chromosomal aberration test in human lymphocytes or the in vivo rat micronucleus assays.

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Patent No. Patent Publication No. Tadalafil has been provided in the form of a liquid formulation by Ajanta, a pharmaceutical company in India, but a suspension formulation rather than a impotence liquid formulation was designed and made commercially available because of the low water solubility of tadalafil.

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